WebThiopental is an ultra-short acting barbiturate and is most commonly used in the induction phase of general anesthesia. Following intravenous injection the drug rapidly reaches the brain and causes unconsciousness within 30–45 seconds. At one minute, the drug attains a peak concentration of about 60% of the total dose in the brain. Thiopental rapidly and easily crosses the blood–brain barrier as it is a lipophilic molecule. As with all lipid-soluble anaesthetic drugs, the short duration of action of sodium thiopental is due almost entirely to its redistribution away from central circulation into muscle and fatty tissue, due to its very high … See more Sodium thiopental, also known as Sodium Pentothal (a trademark of Abbott Laboratories), thiopental, thiopentone, or Trapanal (also a trademark), is a rapid-onset short-acting barbiturate general anesthetic. … See more Anesthesia Sodium thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. Its use has been largely replaced with that of propofol, but may retain some … See more The usual dose range for induction of anesthesia using thiopental is from 3 to 6 mg/kg; however, there are many factors that can alter this. Premedication with sedatives such as benzodiazepines or clonidine will reduce requirements due to drug synergy, … See more Thiopental should be used with caution in cases of liver disease, Addison's disease, myxedema, severe heart disease, severe hypotension, a severe breathing disorder, or a family history of See more Sodium thiopental is a member of the barbiturate class of drugs, which are relatively non-selective compounds that bind to an entire … See more Following a shortage that led a court to delay an execution in California, a company spokesman for Hospira, the sole American manufacturer of the drug, objected to the use … See more As with nearly all anesthetic drugs, thiopental causes cardiovascular and respiratory depression resulting in hypotension See more
Sedative-Hypnotic Drugs Katzung & Trevor
WebThe high lipid solubility of thiopental (in contrast to pentobarbital) may well be responsible for the rapid equilibration with brain, and thus for the ultrashort duration of action. Because of its poor blood supply, depot fat takes up thiopental too slowly to be of great importance in the early events that terminate the anesthetic action of a ... WebApr 5, 2024 · Dissociation, which could be considered a type of moderate sedation, is seen when using medications in the phencyclidine group (eg, ketamine). They cause a disconnection between the... michigan daycare billing childcare
Sodium thiopental - Wikipedia
WebMay 19, 2024 · Penicillin is a medication used to manage and treat a wide range of infections. It is in the beta-lactam antibiotic class of drugs. This activity describes penicillin's indications, action, and contraindications as … WebThiopental thiamylal (Surital) are called thiobarbiturates because they possess a sulfa molecule and are quite similar pharmacologically. Following IV administration 9 The induction of general anesthesia with a thiobarbiturate is usually produced by IV injection of 150 to 300 mg over a 15- to 30-second interval. WebThe short action of thiopental is due to rapid redistribution. rapid renal excretion. rapid metabolism. build up of tolerance. conjugation with serum proteins. 0 explanations Explanations are useful to guide through learning process and confirm that the correct answer is indeed correct. Only registered users can add explanations Facebook Twitter michigan day of rest law