Sialyl lewis x slex
WebFeb 28, 2024 · Sialyl-Lewis x (sLex, CD15s) is a tetra-saccharide on the surface of leukocytes required for E-selectin-mediated rolling, a prerequisite for leukocytes to … WebCell adhesion by ELAM-1 is shown to be mediated by a carbohydrate ligand, sialyl-Lewis X (SLex; NeuAc alpha 2,3Gal beta 1,4(Fuc alpha 1,3)-GlcNAc-), a terminal structure found on cell-surface glycoprotein and glycolipid carbohydrate groups of neutrophils. Expand
Sialyl lewis x slex
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WebApr 8, 2013 · Results Summary. The antibody CD15s (Cat#551344) against carbohydrate antigen sialyl lewis x, gives very good signal strength with low back ground on Western … WebAug 18, 2024 · During my postdoctoral studies in the Sackstein Laboratory, I investigated the role of the tetrassacharide, sialyl-Lewis X (sLeX), in skin tropic T-cells. This work …
WebSep 26, 2024 · The minimal requirement for the binding of leukocytes to endothelial E‑selectins and subsequent transmigration is the epitope of the fucosylated glycan, sialyl Lewis x (sLex), attached to specific cell surface glycoproteins. sLex and its isomer sialyl Lewis a (sLea) have been described in NSCLC, but their functional role in cancer cell … WebJun 21, 2024 · Purpose Endometrial cancer (EC) is the most common gynecological cancer worldwide. Treatment has been improved in recent years, but, in advanced stages, …
WebSep 26, 2024 · The minimal requirement for the binding of leukocytes to endothelial E‑selectins and subsequent transmigration is the epitope of the fucosylated glycan, sialyl … WebThe sialyl Lewis x (SLex) tetrasaccharide is the smallest recognizable ligand for selectins. The selectins constitute a vital part of the inflammatory cascade for recruitment of …
WebFeb 17, 2024 · Membrane-bound glycoproteins rich in sialyl Lewis X (SLex; Neu5Acα2-3Galβ1-4[Fucα1-3]GlcNAcβ-R) and sialyl Lewis A (SLea; Neu5Acα2-3Galβ1-3[Fucα1-4]GlcNAcβ-R), such as mucins or CD44, are known ligands for P- and E-selectin at the surface of endothelial cells, mediating the extravasation of BC cells into the blood stream …
WebMay 3, 1996 · Described is the preparation and use of tetrasaccharide 1, which enables a rapid and preparative scale synthesis of sialyl Lewis X (SLeX) analogs having 1-O- and 2 … bissell crosswave on area rugsWebThe FH6 antibody recognizes Sialyl Lewis X (demeric) on glycolipids or glycoproteins. It also recognizes Sialyl Lewis X with long carbohydrate attachments (Sialyl Lewis X-i). These … bissell crosswave parkettWebMolecule of the Month - November 1996. Carbohydrates are now known to play a vital role in cell-cell recognition processes. One of the most important carbohydrates for humans is … darsh aerospacehttp://www.chm.bris.ac.uk/motm/sla/sialylchime.html darshae brownSialyl Lewis (sLeX), also known as cluster of differentiation 15s (CD15s) or stage-specific embryonic antigen 1 (SSEA-1), is a tetrasaccharide carbohydrate which is usually attached to O-glycans on the surface of cells. It is known to play a vital role in cell-to-cell recognition processes. It is also the means by which … See more Sialyl-Lewis X is a tetrasaccharide composed of a sialic acid, fucose and an N-acetyllactosamine. Its systematic name is 5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine (Neu5Acα2-3Galβ1 … See more Leukocyte homing Sialyl-Lewis is important in leukocyte tethering and rolling. Leukocytes move through the blood … See more The term Lewis in its name comes from the name of a family of people who suffered from a red blood cell incompatibility. The … See more Leukocyte adhesion deficiency Defective synthesis of the sialyl Lewis antigen results in immunodeficiency (leukocyte adhesion deficiency See more • CA19-9 (Sialyl-Lewis A) See more • Chen, G.-Y.; Osada, H.; Santamaria-Babi, L. F.; Kannagi, R. (7 November 2006). "Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes". Proceedings of the National Academy of … See more darsha assant star warsWebThe carbohydrate structure sialyl-Lewis X (SLex) can function as a ligand for E-selectin, formerly known as endothelial leukocyte adhesion molecule-1 (ELAM-1). This study was … bissell crosswave pet bed bath and beyondWebSialyl-Lewis X (sLeX) is a sialylated fucosylated tetrasaccharide, an endogenous antigen. Sialyl-Lewis X is a high-affinity ligand for selectins (E-, P-, and L-selectin). Sialyl-Lewis X … bissell crosswave performance bundle