Oxiapoptophagy
WebJun 24, 2024 · Oxiapoptophagy: A type of cell death induced by some oxysterols T. Nury, A. Zarrouk, +3 authors G. Lizard Published 24 June 2024 Biology, Chemistry British Journal of Pharmacology Oxysterols are oxidized forms of cholesterol generated from cholesterol by auto‐oxidation, enzymatic processes, or both. WebApr 11, 2014 · Altogether, our data demonstrate that oxiapoptophagy including ROS overproduction, apoptosis and autophagy could be a particular type of cell death activated by 7KC which can be inhibited by α-tocopherol. Introduction. Cholesterol oxide products (oxysterols) are oxidized forms of cholesterol or its precursors. These compounds, which …
Oxiapoptophagy
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WebThus, in N2a cells, 7KC induces a mode of cell death by oxiapoptophagy, including criteria of OXIdative stress, APOPTOsis and autoPHAGY, associated with mitochondrial and peroxisomal dysfunction, which is counteracted by RSV, QCT, and API reinforcing the interest for these polyphenols in prevention of diseases associated with increased 7KC … WebMar 24, 2024 · 7-Ketocholesterol Induces Oxiapoptophagy and Inhibits Osteogenic Differentiation in MC3T3-E1 Cells Jing Ouyang, Yaosheng Xiao, +7 authors Longhuo Wu …
WebMay 21, 2024 · In conclusion, oxiapoptophagy (OXIdative stress + APOPTOsis + autophagy) seems to be activated by 7-KC in LMSCs. More studies are needed to better understand the role of 7-KC in the death of LMSCs and the possible effects on the SHh pathway. Keywords: oxysterol; 7-KC; mesenchymal stem cell; apoptosis; autophagy; acute myeloid leukemia; … WebDec 29, 2024 · 25-hydroxycholesterol (25-HC) is an oxysterol synthesized from cholesterol by cholesterol-25-hydroxylase during cholesterol metabolism. The aim of this study was to verify whether 25-HC induces oxiapoptophagy in fibroblasts. 25-HC not only decreased the survival of L929 cells, but also increased the number of cells with condensed chromatin …
WebJul 27, 2024 · In addition, inhibition of G-protein-coupled receptor 183 (GPR183), a receptor of 7α,25-DHC, using GPR183 specific antagonist NIBR189 suppressed 7α,25-DHC-induced … WebOxiapoptophagy is a cell death in which apoptosis, oxidative stress, and autophagy are combined. ... ... Previously, our studies reported the 25-HC-induced extrinsic and intrinsic apoptosis in...
WebJul 26, 2024 · Moreover, we confirmed that 5,6 α-EC and 5,6 β-EC induced oxiapoptophagy through concomitant oxidative stress and caspase-3-mediated apoptosis and autophagy. …
WebAttenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases T. Nury, A. Yammine, I. Ghzaiel, K. Sassi, ... everyday boots womensWebApr 11, 2014 · As 7KC induces numerous side effects (oxidative stress, inflammatory processes, and cell death) [20], the term oxiapoptophagy [12] was suggested to define the complex mode of cell death induced by 7KC on U937 cells including oxidative stress, apoptosis, and probably also autophagy [13]. browning gravy sauceWebInduction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7β-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of α-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3) Steroids 2015 Voir la publication. Induction of oxiapoptophagy, a mixed mode of cell death associated with oxidative stress ... everyday boots for womenWebdefined as ‘oxiapoptophagy’, associated with oxidative stress, apopto-sis and autophagy. Pharmacological inhibitors of oxiapoptophagy, some based upon oxysterol ligands, may have therapeutic potential. Hypercholesterolaemia per se is a risk factor for Alzheimer's disease, even though cholesterol does not pass the blood–brain barrier (BBB). browning green tree farmWebJul 1, 2015 · Furthermore, the different cytotoxic effects associated with 7KC, 7β-OHC and 24S-OHC-induced oxiapoptophagy are attenuated by vitamin E (VitE, α-tocopherol) and DHA which enhances VitE protective effects. In 158N murine oligodendrocytes, our data support the concept that oxiapoptophagy, which can be inhibited by VitE and DHA, could be a ... everyday bottomless brunchWebHesperidin Exhibits Protective Effects against PM 2.5-Mediated Mitochondrial Damage, Cell Cycle Arrest, and Cellular Senescence in Human HaCaT Keratinocytes everyday bootsWebMay 21, 2024 · In conclusion, oxiapoptophagy (OXIdative stress + APOPTOsis + autophagy) seems to be activated by 7-KC in LMSCs. More studies are needed to better understand the role of 7-KC in the death of LMSCs and the possible effects on the SHh pathway. Keywords: oxysterol, 7-KC, mesenchymal stem cell, apoptosis, autophagy, acute myeloid leukemia, … everyday book summary