WebIt is a tyrosine kinase inhibitor that enters a cancer cell and binds to the part of the HER2 protein that sits just beneath the cell's outer membrane. Its effect on the function of other … WebMar 1, 2010 · Lapatinib Quinazolines / therapeutic use* Receptor Cross-Talk / drug effects* Receptor, ErbB-2 / metabolism* Receptors, Estrogen / metabolism Substances …
National Center for Biotechnology Information
Lapatinib inhibits the tyrosine kinase activity associated with two oncogenes, EGFR (epidermal growth factor receptor) and HER2/neu (human EGFR type 2). Over expression of HER2/neu can be responsible for certain types of high-risk breast cancers in women. Like sorafenib, lapatinib is a protein kinase inhibitor shown to decrease tumor-causing breast cancer stem cells. WebHow do breast cancer targeted therapies work? Breast cancer targeted therapy uses drugs that block the growth of breast cancer cells in specific ways. For example, targeted … therapeutics polypharmacy
Lapatinib: MedlinePlus Drug Information
WebJun 8, 2024 · Chemotherapy (anti-cancer) medicines work by inhibiting the way cells grow and increase in number. Lapatinib belongs to a group of anti-cancer medicines known as tyrosine kinase inhibitors. These medicines work by blocking the chemical messengers (called tyrosine kinases) which send signals to cells to grow. WebUses Lapatinib is used to treat a certain type of breast cancer ( HER2 -positive). It works by slowing or stopping the growth of cancer cells. How to use Tykerb Read the Patient Information... WebTrastuzumab treatment does not prevent intracranial seeding and is largely ineffective for established central nervous system metastasis in HER2 overexpressing breast cancer patients. Combination therapy of lapatinib and capecitabine may be an effective treatment option for brain metastasis of HER2-positive breast cancer. We report a patient with … therapeutic specialist role