Foxm1 chip
WebJul 11, 2024 · The Forkhead box protein M1 (FoxM1) is an appealing target for anti-cancer therapeutics as this cell proliferation-associated transcription factor is overexpressed in most human cancers. FoxM1 is involved in tumor invasion, angiogenesis, and metastasis. To discover novel inhibitors that disrupt the FoxM1-DNA interaction, we identified CDI, a … WebAug 16, 2024 · As a transcription factor, FOXM1 binds to its specific binding sites in the promoters or enhancers of its target genes and regulates their transcription. In the TRANSFAC 2.0 database, there are five positional weight matrices for FOXM1, either built from individual genomic binding sites or based on a ChIP-seq dataset. The core binding …
Foxm1 chip
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WebFeb 6, 2024 · FOXM1 inhibition by thiostrepton significantly decreased FOXM1 enrichment in TYMS promoter, further proving that TYMS is a direct target of FOXM1. Our ChIP-seq data confirmed FOXM1 has binding ... WebMar 16, 2009 · To further validate these ChIP fractions, known FOXM1 transcriptional targets such as cyclin B1 (Supplemental Fig. S8A) and VEGF (Supplemental Fig. S8B–C) showed significantly higher copy numbers of respective promoters in the anti-FOXM1 ChIP fractions. FOXM1 did not bind to the promoter of the tumour suppressor p16 (CDKN2A; …
WebSep 9, 2024 · FOXM1, forkhead box protein, is a crucial cell cycle regulator [36, 37], which has been shown to be highly associated with multiple cancer types [38–42]. Recently, … WebJun 19, 2024 · Forkhead box M1 (FOXM1) is a member of the conserved forkhead box (FOX) transcription factor family. Over the last two decades, FOXM1 has emerged as a multifunctional oncoprotein and a robust biomarker of poor prognosis in many human malignancies. In this review article, we address the current knowledge regarding the …
WebJan 24, 2013 · (d) FOXM1 ChIP was performed on DMSO or thiostrepton-treated MCF7 cells and qPCR was used to check FOXM1 binding in regions identified in DBA analysis … WebOct 5, 2024 · Forkhead box M1(FoxM1) played an important role in the pathogenesis of ovarian cancer, but its downstream molecular network is mysterious. Here, we combined ChIP-seq with RNA-seq analysis and identified 687 FoxM1-binding regions and 182 genes regulated by FoxM1. The above data pointed out that KRT5 …
WebAug 21, 2011 · d, FOXM1 ChIP was performed on MCF-7 cells treated for four hours with either DMSO or 1 (10 µM). RT-PCR was performed to investigate binding events at some known and putative FOXM1 binding …
WebBackground. Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis, and cell proliferation. FoxM1 expression increases during G1 and S and reaches maximum levels in G2/M (1-3). cost of propane tank exchange at home depotWebJun 7, 2024 · FoxM1 is an oncogenic transcription factor that has been linked to the genesis and progression of cancer. FoxM1 not only upregulates cell proliferation and survival genes, but also represses tumor suppressor genes according to our prior study. This ChIP-Seq is a part of our endeveavor to creat a map of the FoxM1 occupied chromatin area in order ... breakthrough massage chairWebForkhead box M1 (FOXM1), also named as HNF-3, HFH-11 or Trident, belongs to a superfamily of Fox transcription factors. FOXM1 is strongly associated with cell proliferation, it plays a important role in cell cycle … cost of propane tank refill for bbqWebMar 21, 2024 · FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Protein C Deficiency . Among its … cost of propane tanks residentialWebMar 9, 2024 · FOXM1 Antibody (G-5) is an IgG 2b κ mouse monoclonal FOXM1 antibody (also designated HNF3 antibody, FKHL16 antibody, forkhead box M1 antibody) that detects the FOXM1 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. FOXM1 Antibody (G-5) is available as both the non-conjugated anti-FOXM1 antibody … breakthrough massage chair 5WebTo test whether homologous recombination repair (HRR) depends on FOXO3a, a cellular aging model of human dermal fibroblast (HDF) and tet-on flag-h-FOXO3a transgenic mice were studied. HDF cells transfected with over-expression of wt-h-FOXO3a increased the protein levels of MRE11, BRCA1, BRIP1, and RAD50, while knock-down with siFOXO3a … breakthrough martial arts post fallsWebOct 5, 2024 · FoxM1 promotes the migration of ovarian cancer cell through KRT5 and KRT7 Authors Ziyu Zhang 1 , Kaijia Tu 2 , Faying Liu 1 , Meirong Liang 2 , Kaihui Yu 3 , … breakthrough massage chair in store