Cish protein
WebAug 31, 2024 · We showed that this CISH-mediated tuning was critical to maintain the balance of steady-state protein kinase and transcription factor activities to support lung homeostasis. The SOCS family (including SOCS1 to SOCS7 and CISH) has been extensively studied, and its members have diverse functions in immune regulation … The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be … See more Cytokine-inducible SH2-containing protein is a protein that in humans is encoded by the CISH gene. CISH orthologs have been identified in most mammals with sequenced genomes. CISH controls T cell receptor (TCR) signaling, … See more Model organisms have been used in the study of CISH function. A conditional knockout mouse line, called Cish was generated as part of the International Knockout Mouse Consortium See more • Human CISH genome location and CISH gene details page in the UCSC Genome Browser. See more CISH has been shown to interact with IL2RB and Growth hormone receptor. and PLCG1. See more • Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (May 2002). "The SOCS box: a tale of destruction and degradation". Trends in Biochemical … See more
Cish protein
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WebAs an important member of the suppressors of cytokine signaling (SOCS) protein family, many physiological functions of cytokine-inducible SH2-containing protein (CISH) have been described; however, the role of hepatic CISH in gluconeogenesis is poorly understood. WebSOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that …
WebQuality Control Testing: 12.5% SDS-PAGE Stained with Coomassie Blue. Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. Storage Instruction: Store at -80°C. Aliquot to avoid repeated freezing and thawing. Note: Best use within three months from the date of receipt of this protein. WebCytokine-inducible SH2-containing protein (CISH) involved in regulating metabolism, the expansion of intestinal tuft cells and type-2 innate lymphoid cells, and ageing-related airway inflammation. Here, we investigated the role of CISH in ageing-related colitis susceptibility.
WebCytokine-induced SH-2 containing protein (CISH) is one known family members of SOCS, with its main function involving in regulating the signaling of interleukin-2. In this study, the full-length cDNA sequence of Cyprinus carpio CISH with the length of 1685 bp was cloned. The open reading frame (ORF) was 666 bp in length and encoded 221 amino acids. WebCISH serves a major role in controlling NK cell production and function, which is mediated by its negative regulation of IL-15. CISH is induced by IL-15, which strongly activates …
WebCISH. CISH is a highly sensitive and reliable method for detecting macrolide-resistant H. pylori in formalin-fixed, paraffin-embedded biopsy specimens, which represents the …
WebThe cytokine-inducible SH2-containing protein (CIS, encoded by Cish) is a member of the suppressors of cytokine signaling (SOCS), a family of intracellular proteins that have been show to regulate the activity of a variety of cytokine and growth factor receptors ( 1 ). fitbit daily activity summaryWebJan 14, 2024 · Human Gene CISH (ENST00000348721.4) Description:Homo sapiens cytokine inducible SH2 containing protein (CISH), transcript variant 2, mRNA. (from RefSeq NM_145071) RefSeq Summary (NM_145071):The protein encoded by this gene contains a SH2 domain and a SOCS box domain. can food lower blood pressureWebOct 14, 2024 · Looking into the relationship between PD-1 and other markers of activation, Palmer and Webber et al. noticed something interesting about the expression patterns of CISH (cytokine-induced SH2 protein) and did a deep dive into understanding the biology of what could be an important internal checkpoint regulating T cell reactivity. can food life spanWebWe have especially been interested in the protein CISH (Cytokine-inducible SH2-containing protein), an essential inhibitor protein of lymphocyte signaling pathways. During this postdoctoral internship at NIH (Bethesda, MA, USA), we showed that the absence of CISH promotes the anti-tumor functions of CD8 + lymphocytes. Our studies led to the set ... can food make your poop redWebFluorescence in situ hybridization (FISH) technologies enable rapid detection of chromosome aberrations in all manner of tissues, including both fresh and archival specimens. These technologies have gained broad acceptance in the clinical cytogenetic and research communities. can food labels be misleadingWebIL18 polyclonal antibody. Rabbit polyclonal antibody raised against synthetic protein of IL18. Synthetic protein corresponding to C-terminus of IL18. The optimal working dilution should be determined by the end user. Lyophilized from PBS, pH 7.4 (5% Trehalose). Store at -20°C on dry atmosphere. fitbit dashboard downloadWebThe protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), … fitbit dashboard login canada